67.6 Folate:Active B12
67.6.1 Global tests
Type III ANOVA on main and interaction effects, and LM model summaries.
Prolactin| Chisq | Df | Pr(>Chisq) | ||
|---|---|---|---|---|
| (Intercept) | 250.7924480 | 1 | <0.0001 | *** |
| Study | 3.2136720 | 1 | 0.07 | ns |
| f39_gdm_new | 0.5754347 | 1 | 0.4 | ns |
| BMI | 3.3368238 | 1 | 0.07 | ns |
| Ethnicity_cauc | 105.4219556 | 1 | <0.0001 | *** |
| f10c_any_cig_1st_vst | 49.1590682 | 1 | <0.0001 | *** |
| GA_samp | 164.6323095 | 1 | <0.0001 | *** |
| Study:f39_gdm_new | 1.8652579 | 1 | 0.2 | ns |
| Chisq | Df | Pr(>Chisq) | ||
|---|---|---|---|---|
| (Intercept) | 150.8759535 | 1 | <0.0001 | *** |
| Study | 7.3986291 | 1 | 0.007 | ** |
| f39_gdm_new | 0.4357432 | 1 | 0.5 | ns |
| BMI | 236.2094019 | 1 | <0.0001 | *** |
| Ethnicity_cauc | 5.5165373 | 1 | 0.02 | * |
| f10c_any_cig_1st_vst | 0.9176455 | 1 | 0.3 | ns |
| GA_samp | 2601.9722143 | 1 | <0.0001 | *** |
| Study:f39_gdm_new | 1.4845286 | 1 | 0.2 | ns |
| Chisq | Df | Pr(>Chisq) | ||
|---|---|---|---|---|
| (Intercept) | 251.096669 | 1 | <0.0001 | *** |
| Study | 1.107622 | 1 | 0.3 | ns |
| f39_gdm_new | 1.386104 | 1 | 0.2 | ns |
| BMI | 87.622496 | 1 | <0.0001 | *** |
| Ethnicity_cauc | 3.246832 | 1 | 0.07 | ns |
| f10c_any_cig_1st_vst | 1.039153 | 1 | 0.3 | ns |
| GA_samp | 1032.266869 | 1 | <0.0001 | *** |
| Study:f39_gdm_new | 3.376951 | 1 | 0.07 | ns |
| model term | df1 | df2 | F.ratio | Chisq | p.value | ||
|---|---|---|---|---|---|---|---|
| 1 | Study | 1 | Inf | 21.326 | 21.326 | <0.0001 | *** |
| 3 | f39_gdm_new | 1 | Inf | 33.726 | 33.726 | <0.0001 | *** |
| 4 | BMI | 1 | Inf | 330.722 | 330.722 | <0.0001 | *** |
| 5 | Ethnicity_cauc | 1 | Inf | 25.046 | 25.046 | <0.0001 | *** |
| 6 | f10c_any_cig_1st_vst | 1 | Inf | 3.158 | 3.158 | 0.08 | ns |
| 7 | GA_samp | 1 | Inf | 2.506 | 2.506 | 0.1 | ns |
| 2 | Study:f39_gdm_new | 1 | Inf | 4.089 | 4.089 | 0.04 | * |
| model term | df1 | df2 | F.ratio | Chisq | p.value | ||
|---|---|---|---|---|---|---|---|
| 1 | Study | 1 | Inf | 36.051 | 36.051 | <0.0001 | *** |
| 3 | f39_gdm_new | 1 | Inf | 32.027 | 32.027 | <0.0001 | *** |
| 4 | BMI | 1 | Inf | 316.807 | 316.807 | <0.0001 | *** |
| 5 | Ethnicity_cauc | 1 | Inf | 24.882 | 24.882 | <0.0001 | *** |
| 6 | f10c_any_cig_1st_vst | 1 | Inf | 2.618 | 2.618 | 0.1 | ns |
| 7 | GA_samp | 1 | Inf | 1.602 | 1.602 | 0.2 | ns |
| 2 | Study:f39_gdm_new | 1 | Inf | 4.361 | 4.361 | 0.04 | * |
| model term | df1 | df2 | F.ratio | Chisq | p.value | ||
|---|---|---|---|---|---|---|---|
| 1 | Study | 1 | Inf | 53.182 | 53.182 | <0.0001 | *** |
| 3 | f39_gdm_new | 1 | Inf | 4.345 | 4.345 | 0.04 | * |
| 4 | BMI | 1 | Inf | 11.449 | 11.449 | 0.0007 | *** |
| 5 | Ethnicity_cauc | 1 | Inf | 0.718 | 0.718 | 0.4 | ns |
| 6 | f10c_any_cig_1st_vst | 1 | Inf | 0.028 | 0.028 | 0.9 | ns |
| 7 | GA_samp | 1 | Inf | 0.278 | 0.278 | 0.6 | ns |
| 2 | Study:f39_gdm_new | 1 | Inf | 1.558 | 1.558 | 0.2 | ns |
67.6.2 Model summary
Ratio of Geometric means (95% CI)
Prolactin| Var | Effect | P |
|---|---|---|
| (Intercept) | 2.93 (2.45, 3.41) | <0.0001 |
| folate_Active.B12 | -0.00 (-0.00, 0.00) | 0.05 |
| f39_gdm_newGDM | -0.24 (-0.55, 0.07) | 0.13 |
| StudySTOP | -0.23 (-0.40, -0.06) | 0.008 |
| GA_samp | 0.13 (0.10, 0.16) | <0.0001 |
| folate_Active.B12:f39_gdm_newGDM | 0.00 (-0.00, 0.00) | 0.60 |
| f39_gdm_newGDM:StudySTOP | 0.21 (-0.10, 0.52) | 0.17 |
| folate_Active.B12:StudySTOP | 0.00 (0.00, 0.00) | 0.03 |
| Var | Effect | P |
|---|---|---|
| (Intercept) | 0.67 (0.42, 0.93) | <0.0001 |
| folate_Active.B12 | 0.00 (-0.00, 0.00) | 0.65 |
| f39_gdm_newGDM | -0.13 (-0.28, 0.02) | 0.09 |
| StudySTOP | 0.16 (0.07, 0.25) | 0.0005 |
| GA_samp | 0.29 (0.27, 0.30) | <0.0001 |
| folate_Active.B12:f39_gdm_newGDM | 0.00 (-0.00, 0.00) | 0.53 |
| f39_gdm_newGDM:StudySTOP | 0.11 (-0.04, 0.26) | 0.15 |
| folate_Active.B12:StudySTOP | -0.00 (-0.00, -0.00) | 0.02 |
| Var | Effect | P |
|---|---|---|
| (Intercept) | -2.68 (-3.03, -2.34) | <0.0001 |
| folate_Active.B12 | -0.00 (-0.00, 0.00) | 0.13 |
| f39_gdm_newGDM | -0.17 (-0.38, 0.05) | 0.13 |
| StudySTOP | -0.07 (-0.19, 0.06) | 0.28 |
| GA_samp | 0.27 (0.25, 0.29) | <0.0001 |
| folate_Active.B12:f39_gdm_newGDM | -0.00 (-0.00, 0.00) | 0.89 |
| f39_gdm_newGDM:StudySTOP | 0.18 (-0.04, 0.40) | 0.11 |
| folate_Active.B12:StudySTOP | 0.00 (-0.00, 0.00) | 0.29 |
| Var | Effect | P |
|---|---|---|
| (Intercept) | 2.66 (2.05, 3.26) | <0.0001 |
| folate_Active.B12 | -0.00 (-0.00, 0.00) | 0.66 |
| f39_gdm_newGDM | 0.97 (0.43, 1.51) | 0.0004 |
| StudySTOP | -0.31 (-0.54, -0.07) | 0.01 |
| GA_samp | 0.01 (-0.03, 0.04) | 0.74 |
| folate_Active.B12:f39_gdm_newGDM | -0.00 (-0.00, 0.00) | 0.69 |
| f39_gdm_newGDM:StudySTOP | -0.35 (-0.96, 0.25) | 0.25 |
| folate_Active.B12:StudySTOP | -0.00 (-0.00, 0.00) | 0.89 |
| folate_Active.B12:f39_gdm_newGDM:StudySTOP | -0.00 (-0.00, 0.00) | 0.68 |
| Var | Effect | P |
|---|---|---|
| (Intercept) | 1.36 (0.71, 2.00) | <0.0001 |
| folate_Active.B12 | -0.00 (-0.00, 0.00) | 0.65 |
| f39_gdm_newGDM | 1.04 (0.42, 1.66) | 0.001 |
| StudySTOP | -0.47 (-0.73, -0.22) | 0.0002 |
| GA_samp | -0.00 (-0.04, 0.04) | 0.94 |
| folate_Active.B12:f39_gdm_newGDM | -0.00 (-0.00, 0.00) | 0.65 |
| f39_gdm_newGDM:StudySTOP | -0.37 (-1.06, 0.32) | 0.29 |
| folate_Active.B12:StudySTOP | -0.00 (-0.00, 0.00) | 0.89 |
| folate_Active.B12:f39_gdm_newGDM:StudySTOP | -0.00 (-0.00, 0.00) | 0.60 |
| Var | Effect | P |
|---|---|---|
| (Intercept) | 1.81 (1.68, 1.95) | <0.0001 |
| folate_Active.B12 | -0.00 (-0.00, 0.00) | 0.16 |
| f39_gdm_newGDM | 0.17 (-0.01, 0.36) | 0.07 |
| StudySTOP | -0.16 (-0.20, -0.11) | <0.0001 |
| GA_samp | -0.01 (-0.02, 0.00) | 0.10 |
| folate_Active.B12:f39_gdm_newGDM | -0.00 (-0.00, 0.00) | 0.08 |
| f39_gdm_newGDM:StudySTOP | -0.13 (-0.31, 0.05) | 0.15 |
| folate_Active.B12:StudySTOP | 0.00 (-0.00, 0.00) | 0.79 |
67.6.3 Estimated means
Estimated marginal means (or adjusted means) adjusted for GA at sampling.
Results are averaged over the levels of Folate:Active B12 ratio and may be misleading when interaction term is involved.
| Study | f39_gdm_new | response | SE | df | lower.CL | upper.CL |
|---|---|---|---|---|---|---|
| SCOPE | non-GDM | 103.67295 | 8.607879 | 98.74735 | 87.92535 | 122.2410 |
| STOP | non-GDM | 91.59491 | 7.337537 | 85.97214 | 78.11050 | 107.4072 |
| SCOPE | GDM | 84.74948 | 13.335572 | 646.80044 | 62.22243 | 115.4322 |
| STOP | GDM | 92.62091 | 9.551892 | 215.33962 | 75.58393 | 113.4981 |
| Study | f39_gdm_new | response | SE | df | lower.CL | upper.CL |
|---|---|---|---|---|---|---|
| SCOPE | non-GDM | 93.68393 | 2.807221 | 204.3840 | 88.30943 | 99.38552 |
| STOP | non-GDM | 103.51862 | 2.950107 | 171.1750 | 97.85610 | 109.50880 |
| SCOPE | GDM | 84.16705 | 5.935862 | 553.3811 | 73.27903 | 96.67284 |
| STOP | GDM | 104.09156 | 4.692758 | 537.1804 | 95.26956 | 113.73048 |
| Study | f39_gdm_new | response | SE | df | lower.CL | upper.CL |
|---|---|---|---|---|---|---|
| SCOPE | non-GDM | 2.424603 | 0.0833960 | 340.9341 | 2.265994 | 2.594315 |
| STOP | non-GDM | 2.353344 | 0.0753146 | 311.0320 | 2.209722 | 2.506299 |
| SCOPE | GDM | 2.035655 | 0.2011072 | 715.8881 | 1.676755 | 2.471376 |
| STOP | GDM | 2.364709 | 0.1320586 | 607.8943 | 2.119079 | 2.638812 |
| Study | f39_gdm_new | response | SE | df | asymp.LCL | asymp.UCL |
|---|---|---|---|---|---|---|
| SCOPE | non-GDM | 15.14587 | 0.9305930 | Inf | 13.427488 | 17.08417 |
| STOP | non-GDM | 11.03849 | 0.5683307 | Inf | 9.978941 | 12.21054 |
| SCOPE | GDM | 38.40424 | 7.6683352 | Inf | 25.966668 | 56.79919 |
| STOP | GDM | 18.65766 | 1.9151286 | Inf | 15.257560 | 22.81547 |
| Study | f39_gdm_new | response | SE | df | asymp.LCL | asymp.UCL |
|---|---|---|---|---|---|---|
| SCOPE | non-GDM | 3.705064 | 0.2450049 | Inf | 3.254680 | 4.217773 |
| STOP | non-GDM | 2.283943 | 0.1252114 | Inf | 2.051258 | 2.543022 |
| SCOPE | GDM | 10.010554 | 2.3228700 | Inf | 6.352483 | 15.775121 |
| STOP | GDM | 3.959116 | 0.4342997 | Inf | 3.193190 | 4.908759 |
| Study | f39_gdm_new | response | SE | df | asymp.LCL | asymp.UCL |
|---|---|---|---|---|---|---|
| SCOPE | non-GDM | 5.505121 | 0.0619100 | Inf | 5.385107 | 5.627809 |
| STOP | non-GDM | 4.722670 | 0.0538362 | Inf | 4.618323 | 4.829374 |
| SCOPE | GDM | 6.276927 | 0.5367242 | Inf | 5.308391 | 7.422174 |
| STOP | GDM | 4.726920 | 0.0774446 | Inf | 4.577542 | 4.881171 |
67.6.4 Comparisons
67.6.4.1 Within Groups
Effect for every 500 unit increase in Folate:Active B12 ratio.| Hormone | Contrast | Study | f39_gdm_new | Ratio of Geometric means (95% CI) | P-value |
|---|---|---|---|---|---|
| Prolactin | folate_Active.B121123.57 / folate_Active.B12623.57 | SCOPE | non-GDM | 0.965 (0.931, 1.000) | 0.05 |
| Prolactin | folate_Active.B121123.57 / folate_Active.B12623.57 | STOP | non-GDM | 1.025 (0.983, 1.070) | 0.2 |
| Prolactin | folate_Active.B121123.57 / folate_Active.B12623.57 | SCOPE | GDM | 0.986 (0.907, 1.073) | 0.7 |
| Prolactin | folate_Active.B121123.57 / folate_Active.B12623.57 | STOP | GDM | 1.048 (0.975, 1.126) | 0.2 |
| HPL | folate_Active.B121123.57 / folate_Active.B12623.57 | SCOPE | non-GDM | 1.004 (0.986, 1.023) | 0.6 |
| HPL | folate_Active.B121123.57 / folate_Active.B12623.57 | STOP | non-GDM | 0.970 (0.948, 0.993) | 0.010 |
| HPL | folate_Active.B121123.57 / folate_Active.B12623.57 | SCOPE | GDM | 1.018 (0.974, 1.064) | 0.4 |
| HPL | folate_Active.B121123.57 / folate_Active.B12623.57 | STOP | GDM | 0.983 (0.946, 1.022) | 0.4 |
| GH2 | folate_Active.B121123.57 / folate_Active.B12623.57 | SCOPE | non-GDM | 0.980 (0.956, 1.006) | 0.1 |
| GH2 | folate_Active.B121123.57 / folate_Active.B12623.57 | STOP | non-GDM | 1.002 (0.970, 1.036) | 0.9 |
| GH2 | folate_Active.B121123.57 / folate_Active.B12623.57 | SCOPE | GDM | 0.976 (0.917, 1.039) | 0.4 |
| GH2 | folate_Active.B121123.57 / folate_Active.B12623.57 | STOP | GDM | 0.998 (0.946, 1.053) | 0.9 |
| Insulin | folate_Active.B121123.57 / folate_Active.B12623.57 | SCOPE | non-GDM | 0.986 (0.927, 1.049) | 0.7 |
| Insulin | folate_Active.B121123.57 / folate_Active.B12623.57 | STOP | non-GDM | 0.981 (0.931, 1.033) | 0.5 |
| Insulin | folate_Active.B121123.57 / folate_Active.B12623.57 | SCOPE | GDM | 0.966 (0.889, 1.049) | 0.4 |
| Insulin | folate_Active.B121123.57 / folate_Active.B12623.57 | STOP | GDM | 0.931 (0.851, 1.019) | 0.1 |
| HOMA.IR | folate_Active.B121123.57 / folate_Active.B12623.57 | SCOPE | non-GDM | 0.985 (0.921, 1.053) | 0.7 |
| HOMA.IR | folate_Active.B121123.57 / folate_Active.B12623.57 | STOP | non-GDM | 0.979 (0.926, 1.034) | 0.4 |
| HOMA.IR | folate_Active.B121123.57 / folate_Active.B12623.57 | SCOPE | GDM | 0.958 (0.870, 1.055) | 0.4 |
| HOMA.IR | folate_Active.B121123.57 / folate_Active.B12623.57 | STOP | GDM | 0.913 (0.833, 1.001) | 0.05 |
| GLUC3_mmol.L | folate_Active.B121123.57 / folate_Active.B12623.57 | SCOPE | non-GDM | 0.996 (0.989, 1.002) | 0.2 |
| GLUC3_mmol.L | folate_Active.B121123.57 / folate_Active.B12623.57 | STOP | non-GDM | 0.997 (0.985, 1.010) | 0.7 |
| GLUC3_mmol.L | folate_Active.B121123.57 / folate_Active.B12623.57 | SCOPE | GDM | 0.973 (0.947, 1.000) | 0.05 |
| GLUC3_mmol.L | folate_Active.B121123.57 / folate_Active.B12623.57 | STOP | GDM | 0.975 (0.955, 0.995) | 0.01 |
67.6.4.2 Between Groups
Below are comparisons of the differences in the change in Folate:Active B12 ratio between groups. I.e. whether the change in Folate:Active B12 ratio are different between groups.
| contrast | ratio | SE | df | lower.CL | upper.CL | p.value | |
|---|---|---|---|---|---|---|---|
| SCOPE/SCOPE (Overall) | 1.129008 | 0.0624241 | 1070.3772 | 1.0129309 | 1.258387 | 0.028 | * |
| STOP/SCOPE (non-GDM) | 1.062548 | 0.0293747 | 1070.3772 | 1.0064447 | 1.121778 | 0.028 | * |
| STOP/SCOPE (GDM) | 1.062548 | 0.0293747 | 1070.3772 | 1.0064447 | 1.121778 | 0.028 | * |
| GDM/non-GDM (SCOPE) | 1.021830 | 0.0416747 | 972.1293 | 0.9432344 | 1.106975 | 0.597 | ns |
| GDM/non-GDM (STOP) | 1.021830 | 0.0416747 | 972.1293 | 0.9432344 | 1.106975 | 0.597 | ns |
| contrast | ratio | SE | df | lower.CL | upper.CL | p.value | |
|---|---|---|---|---|---|---|---|
| SCOPE/SCOPE (Overall) | 0.9332675 | 0.0273714 | 1027.9503 | 0.8810737 | 0.9885533 | 0.019 | * |
| STOP/SCOPE (non-GDM) | 0.9660577 | 0.0141665 | 1027.9503 | 0.9386552 | 0.9942602 | 0.019 | * |
| STOP/SCOPE (GDM) | 0.9660577 | 0.0141665 | 1027.9503 | 0.9386552 | 0.9942602 | 0.019 | * |
| GDM/non-GDM (SCOPE) | 1.0135354 | 0.0219233 | 891.5394 | 0.9714087 | 1.0574889 | 0.534 | ns |
| GDM/non-GDM (STOP) | 1.0135354 | 0.0219233 | 891.5394 | 0.9714087 | 1.0574889 | 0.534 | ns |
| contrast | ratio | SE | df | lower.CL | upper.CL | p.value | |
|---|---|---|---|---|---|---|---|
| SCOPE/SCOPE (Overall) | 1.0448347 | 0.0434404 | 1080.3324 | 0.9629818 | 1.133645 | 0.292 | ns |
| STOP/SCOPE (non-GDM) | 1.0221715 | 0.0212491 | 1080.3324 | 0.9813163 | 1.064728 | 0.292 | ns |
| STOP/SCOPE (GDM) | 1.0221715 | 0.0212491 | 1080.3324 | 0.9813163 | 1.064728 | 0.292 | ns |
| GDM/non-GDM (SCOPE) | 0.9956797 | 0.0302511 | 977.0011 | 0.9380501 | 1.056850 | 0.887 | ns |
| GDM/non-GDM (STOP) | 0.9956797 | 0.0302511 | 977.0011 | 0.9380501 | 1.056850 | 0.887 | ns |
| contrast | ratio | SE | df | asymp.LCL | asymp.UCL | p.value | |
|---|---|---|---|---|---|---|---|
| SCOPE/SCOPE (Overall) | 0.9587955 | 0.0717422 | Inf | 0.8280079 | 1.110242 | 0.574 | ns |
| STOP/SCOPE (non-GDM) | 0.9942499 | 0.0408609 | Inf | 0.9173046 | 1.077650 | 0.888 | ns |
| STOP/SCOPE (GDM) | 0.9643405 | 0.0603443 | Inf | 0.8530331 | 1.090172 | 0.562 | ns |
| GDM/non-GDM (SCOPE) | 0.9792031 | 0.0517149 | Inf | 0.8829132 | 1.085994 | 0.691 | ns |
| GDM/non-GDM (STOP) | 0.9497463 | 0.0504299 | Inf | 0.8558748 | 1.053913 | 0.332 | ns |
| contrast | ratio | SE | df | asymp.LCL | asymp.UCL | p.value | |
|---|---|---|---|---|---|---|---|
| SCOPE/SCOPE (Overall) | 0.9471149 | 0.0769590 | Inf | 0.8076762 | 1.110627 | 0.504 | ns |
| STOP/SCOPE (non-GDM) | 0.9938934 | 0.0442180 | Inf | 0.9108989 | 1.084450 | 0.890 | ns |
| STOP/SCOPE (GDM) | 0.9529341 | 0.0648199 | Inf | 0.8339941 | 1.088837 | 0.478 | ns |
| GDM/non-GDM (SCOPE) | 0.9728165 | 0.0584730 | Inf | 0.8647047 | 1.094445 | 0.647 | ns |
| GDM/non-GDM (STOP) | 0.9327258 | 0.0510453 | Inf | 0.8378577 | 1.038336 | 0.203 | ns |
| contrast | ratio | SE | df | asymp.LCL | asymp.UCL | p.value | |
|---|---|---|---|---|---|---|---|
| SCOPE/SCOPE (Overall) | 1.0038962 | 0.0144286 | Inf | 0.9760112 | 1.032578 | 0.787 | ns |
| STOP/SCOPE (non-GDM) | 1.0019462 | 0.0072003 | Inf | 0.9879328 | 1.016158 | 0.787 | ns |
| STOP/SCOPE (GDM) | 1.0019462 | 0.0072003 | Inf | 0.9879328 | 1.016158 | 0.787 | ns |
| GDM/non-GDM (SCOPE) | 0.9772807 | 0.0126769 | Inf | 0.9527476 | 1.002446 | 0.076 | ns |
| GDM/non-GDM (STOP) | 0.9772807 | 0.0126769 | Inf | 0.9527476 | 1.002446 | 0.076 | ns |